Frame that gene

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Frame that gene

Enabling the public to understand scientific concepts and advances, and the issues they raise, is an increasingly important challenge for scientists and politicians alike. public opinion—received via polls and elections—can influence scientific policy-making, and hence affect the funding and even the nature or focus of research itself. the fierce dispute over genetically modified crops in Europ...

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This paper describes the supervised acquisition of semantic event frames based on a corpus of biomedical abstracts, in which the biological process of E. coli gene regulation has been linguistically annotated by a group of biologists in the EC research project "BOOTStrep". Gene regulation is one of the rapidly advancing areas for which information extraction could boost research. Event frames a...

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Reading-frame restoration with an apolipoprotein B gene frameshift mutation.

We examined a mutant human apolipoprotein B (apoB) allele that causes hypobetalipoproteinemia and has a single cytosine deletion in exon 26. This frameshift mutation was associated with the synthesis of a truncated apoB protein of the predicted size; however, studies in human subjects and minigene expression studies in cultured cells indicated that the mutant allele also yielded a full-length a...

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A Probabilistic Genome-Wide Gene Reading Frame Sequence Model

We introduce a new type of probabilistic sequence model, that model the sequential composition of reading frames of genes in a genome. Our approach extends gene finders with a model of the sequential composition of genes at the genome-level – effectively producing a sequential genome annotation as output. The model can be used to obtain the most probable genome annotation based on a combination...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2008

ISSN: 1469-221X,1469-3178

DOI: 10.1038/embor.2008.176